I’ve noticed that just about every year or so I favor larger type for body / paragraph text. A while back I moved from 16px (100%) to 18px (112.5%) and today I decided to increase that to 20px (125%) for screens larger than 900px. I’ve been hesitant to worry too much about extra-large responsive views on this blog because I didn’t want to completely blowout the ideal range for characters-per-line, but the larger font-size keeps things nice and proportional.
This is why, typographically speaking, fluid layouts fail without the power of media queries. Increasing your font-size as a column widens can keep you within that safe 45 to 75 characters per line range, and keep readers happy.